Should recombinant human growth hormone therapy be used in short small for gestational age children?
نویسندگان
چکیده
Short small for gestational age (SGA) children represent 20% of all children with short stature and therefore constitute a significant portion of the caseload in a growth clinic. The recent approval of recombinant human growth hormone (GH) for the treatment of short stature in SGA children by the European Union's Committee on Proprietary Medicinal Products offers a new licensed therapeutic option. This article examines the role of GH therapy in short SGA children with particular reference to selection of patients, effectiveness, safety, and its potential metabolic implications.
منابع مشابه
RECENT ADVANCES Should recombinant human growth hormone therapy be used in short small for gestational age children?
Short small for gestational age (SGA) children represent 20% of all children with short stature and therefore constitute a significant portion of the caseload in a growth clinic. The recent approval of recombinant human growth hormone (GH) for the treatment of short stature in SGA children by the European Union’s Committee on Proprietary Medicinal Products offers a new licensed therapeutic opti...
متن کاملGrowth Hormone Therapy for Short Children Born Small for Gestational Age
Children born small for gestational age may demonstrate continued growth retardation, resulting in persistent short stature. In the majority of the cases, this is linked with abnormal growth hormone secretion and also abnormal insulinlike growth factor levels. This review discusses the treatment of such children with recombinant human growth hormone. It illustrates the importance of starting th...
متن کاملEfficacy and safety of growth hormone treatment for children born small for gestational age
Recombinant growth hormone (GH) is an effective treatment for short children who are born small for gestational age (SGA). Short children born SGA who fail to demonstrate catch-up growth by 2-4 years of age are candidates for GH treatment initiated to achieve catch-up growth to a normal height in early childhood, maintain a normal height gain throughout childhood, and achieve an adult height wi...
متن کاملReduced insulin sensitivity during growth hormone therapy for short children born small for gestational age.
OBJECTIVES To examine the influence of recombinant human growth hormone (rhGH) therapy on insulin sensitivity in short children born small for gestational age (SGA). STUDY DESIGN Twelve short (height standard deviation score, -3.2 +/- 0.1) non-GH-deficient children SGA (7 boys/5 girls) were studied at 9.3 +/- 1.0 years of age. The insulin sensitivity index was measured with Bergman's minimal ...
متن کاملComparative evaluation of short-term biomarker response to treatment for growth hormone deficiency in Chinese children with growth hormone deficiency born small for or appropriate for gestational age: a randomized phase IV open-label study
OBJECTIVES To compare the response between Chinese children with growth hormone deficiency (GHD) born either small for gestational age (SGA) or appropriate for gestational age (AGA) after 4 weeks of recombinant human growth hormone (r-hGH) therapy. METHODS This was a phase IV, open-label, multicenter, interventional study (NCT01187550). Prepubertal children with GHD received open-label treatm...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 89 8 شماره
صفحات -
تاریخ انتشار 2004